IMR Press / EJGO / Volume 41 / Issue 1 / DOI: 10.31083/j.ejgo.2020.01.4758
Open Access Original Research
High-dose-rate intracavitary brachytherapy for non-palpable and non-visible recurrent vaginal stump tumors after hysterectomy
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1 Department of Radiology, Nihon University School of Medicine, Itabashi-ku, Tokyo, Japan
2 Sonodakai Radiation Oncology Clinic, Adachi-ku, Tokyo, Japan
Eur. J. Gynaecol. Oncol. 2020 , 41(1), 54–59; https://doi.org/10.31083/j.ejgo.2020.01.4758
Published: 15 February 2020
Abstract

Purpose: The purpose of this study was to evaluate patients who were treated with high-dose-rate (HDR) intracavitary brachytherapy for non-palpable and non-visible recurrent vaginal stump that occurred after hysterectomy. Materials and Methods: This retrospective study included 11 patients aged 52-81 (median, 61) years. The HDR brachytherapy was performed using a remote after-loading system (RALS). The dose per fraction was planned at mainly 4 Gy/fraction, twice per week, for a total of 32 Gy. Results: CR and PR were diagnosed on cytology or visual examination in nine (82%) patients and in one (9%) patient, respectively. SD was noted in one (9%) patient. Isolated stump recurrence developed in five patients and the three-year LC rate was 53%. There was no severe acute and late toxicity. Conclusion: Local salvage is possible with a three-year LC rate of 53% with regard to non-palpable and non-visible limited vaginal recurrence of gynecological cancer that responds to HDR brachytherapy (4 Gy/fraction, total 32 Gy).

Keywords
High-dose-rate intracavitary brachytherapy
Recurrent vaginal stump
Hysterectomy
Remote after-loading system
Gynecological cancer
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