IMR Press / RCM / Volume 21 / Issue 3 / DOI: 10.31083/j.rcm.2020.03.78
Open Access Systematic Review
SARS-CoV-2 infection in patients with diabetes mellitus and hypertension: a systematic review
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1 Student Research committee, School of medicine, Shahid Beheshti University of Medical Sciences, Tehran 1983969411, Iran
2 Student Research Committee, Babol University of Medical Sciences, Babol 4717647745, Iran
3 Student Research Committee, Dental Faculty, Tehran Medical sciences, Islamic Azad University, Tehran 1946853314, Iran
4 Student Research Committee, School of International Campus, Guilan University of Medical Sciences, Rasht 4199613776, Iran
5 Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz 5166616471, Iran
Rev. Cardiovasc. Med. 2020 , 21(3), 385–397;
Submitted: 30 April 2020 | Revised: 2 September 2020 | Accepted: 7 September 2020 | Published: 30 September 2020

After the emergence of the novel 2019 coronavirus disease in P. R. China, this highly contagious disease has been currently spread out to almost all countries, worldwide. Novel 2019 coronavirus disease, Middle East respiratory syndrome, and severe acute respiratory syndrome are reported to cause a higher risk for severe infections in patients with chronic comorbidities, such as hypertension and diabetes. These severe infections can contribute to higher rates of morbidity and mortality in these patients. In the present review, we discussed the role and underlying mechanisms of the two most common chronic diseases, type-2 diabetes mellitus and hypertension, in clinical manifestations and disease severity of novel 2019 coronavirus disease, Middle East respiratory syndrome and severe acute respiratory syndrome, with the hope to provide evidence for better decision-making in the treatment of this vulnerable population.

Diabetes mellitus
Fig. 1.
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