Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.
Therapeutic prospects of natural alpha interferon from normal human leucocytes in the treatment of genital condylomata in HIV positive women
Various Authors underline that HIV positive women have a higher CIN incidence and a higher prevalence of HPV. HIV could act as cofactor in the proliferation of HPV manifestation, because of a hypothetical deficit of local immunity. 5 HIV positive patients have been examined: 3 of them presenting vulvocondylomas and/or VIN were treated with 1.000.000 IU alpha IFNn three times a week for three weeks. 2 of them presenting CIN and/or HPV were treated with a two-phase therapy: A) Induction therapy: 3.000.000 IU 3 times a week for three cycles. B) Maintenance therapy: 1.000.000 IU 3 times a week for three months. IFN was the primary treatment for viral lesions, even though an improvement of prognostic indices (CD4, CD4/CDB, 2M), has shown its usefulness in association or in alternative to AZT.