Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.
Urinary excretion of relaxin after estradiol treatment of postrnenopausal women
The influence of estradiol treatment on the urinary excretion of relaxin, a hormmone in earlier years only found during pregnancy and presently associated with functions in the cardiovascular system，was investigated in postmenopausal women. Thirteen postmenopausal women were treated with transdermal estradiol and 12 women with oral estradio1 for 4 weeks. Anew radioimmunoassay for human-relaxin (rec-hRLX-2) was used. With transdermal, but not withoral administration, a significant increase of urinary relaxin excretion was registered. Further experiments are necessary to elucidate the source of urinary relaxin and its role in the hormone replacement therapy of postmenopausal women.