Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.
Effects of the association of androgen/estrogen on the bladder and urethra of castrated rats
Purpose: To study the effects of methyltestosterone, isolated or associated to estrogens, on the bladder and urethra of castrated adult rats. Material & Methods: A total of 59 castrated animals were studied. They were divided into the following groups: I - placebo; II - equine conjugated estrogens; III - methyltestosterone and conjugated estrogens; IV - methyltestosterone. After 28 days of medication the animals were sacrificed and bladder and urethra cuts were obtained for the evaluation of the number of vessels, the thickness of the epithelia, and the quantity of collagen and muscular fibers. Results: The group receiving the androgen/estrogen association presented a higher number of vessels, epithelial thickness and quantity of muscular fibers (p <0.05). A smaller quantity of collagen fibers was observed in the group utilizing isolated conjugated estrogen (p <0.05) Conclusion: We concluded that the association of androgen/estrogen positively modifies important parameters in the unnary continence mechanism. Therefore, it could constitute an option for hormone replacement in postmenopausal stress urinary incontinence cases.