IMR Press / CEOG / Volume 35 / Issue 4 / pii/1630639219188-1274459805

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Original Research
Lipid peroxidation and antioxidant status in hypertensive pregnancies
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1 Department of Biochemistry
2 Department of Obstetrics and Gynaecology, J.N. Medical College Nehru, Karnataka (India)
Clin. Exp. Obstet. Gynecol. 2008, 35(4), 275–278;
Published: 10 December 2008
Abstract

Aims and Objective: The present study was designed to evaluate the lipid peroxidation and non-enzymatic antioxidant status in hypertensive complications during pregnancy (preeclamptic and eclamptic) compared with healthy pregnant and non-pregnant patients as controls. Materials and Methods: 25 healthy non-pregnant women as controls, 25 third trimester normal pregnant women and 25 preeclamptic and 25 eclamptic patients of the same trimester. Lipid peroxidation as a thiobarbituric acid reactive substance reduced glutathione, Vitamin E, Vitamin C and Vitamin A. Results: Lipid peroxidation was significantly elevated and significantly decreased levels of antioxidants were found in preeclamptic and eclamptic patients as compared with normal pregnant and control subjects. Conclusion: Our study gives support to those few studies considering lipid peroxidation as an important factor in the pathogenesis of preeclampsia and eclampsia. The decrease in antioxidants, probably of a compensatory nature responding to the increased peroxide load in preeclampsia and eclampsia, may reflect the severity of the disease.
Keywords
Lipid peroxidation
Malondialdehyde
Preeclampsia
Eclampsia
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