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Original Research
Transient ligation of umbilical vessels elevates placental tissue oxygen index (TOI) values measured by near-infrared spectroscopy (NIRS) in clawn miniature pig animal model
K. Suzukin1, H. Itoh1,*, K. Muramatsu1, K. Yamazaki1, K. Nagahashi1, N. Furuta1, N. Tamura1, T. Uchida1, K. Sugihara1, K. Sumimoto2, N. Kanayama1
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1
Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine, Hamamatsu
1
2Department of Nursing, Kawasaki City College of Nursing, Kawasaki (Japan)
Clin. Exp. Obstet. Gynecol. 2012, 39(3), 293–298;
Published: 10 September 2012
Abstract
We recently found a significant elevation in placental tissue oxygen index (TOI) values in cases of fetal growth restriction using near-infrared spectroscopy (NIRS), indicating high oxygenation in the placental tissue. We hypothesized that insufficient fetoumbilical blood flow is causatively associated with high oxygenation levels in placental tissue. We transiently (for 15 sec) ligated the whole umbilicus, umbilical arteries, or veins of pregnant Clawn miniature pigs (102-113 days of gestation) and assessed the changes in TOI values of the placenta and fetus. The ligation significantly increased placental TOI values (p < 0.01, respectively), but concomitantly decreased fetal TOI values (p < 0.01, respectively), suggesting a decline in oxygen inflow from the maternal to fetal circulation in the placental tissue to be causative of the elevated placental TOI values. These observations suggest the promising clinical use of placental TOI values measured noninvasively by the transabdominal application of NIRS to assess the fetoplacental circulation.
Keywords
Placenta
Pregnancy
Near-infrared spectroscopy (NIRS)
Umbilical