IMR Press / CEOG / Volume 41 / Issue 6 / DOI: 10.12891/ceog18772014
Open Access Original Research
Vaginal preparation with povidone iodine disinfection and saline douching as a safe and effective method in prevention of oocyte pickup-associated pelvic inflammation without spoiling the reproductive outcome: evidence from a large cohort study
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1 IVF Center, Oak Clinic, Nishinari-ku, Osaka (Japan)
Clin. Exp. Obstet. Gynecol. 2014 , 41(6), 689–690;
Published: 10 December 2014

Purpose of investigation: The aim of this study was to investigate if vaginal preparation procedure affects the occurrence of oocyte pickup-associated pelvic inflammation (OPU-PI) and the reproductive outcome in an in vitro fertilization (IVF) program. Materials and Methods: The occurrence of OPU-PI and the reproductive outcome were compared between 956 infertile patients undergoing vaginal preparation with saline douching alone versus 1,216 infertile patients undergoing a combination of povidone iodine disinfection and subsequent saline douching in an IVF program. Results: OPU-PI occurred in four patients (0.042%) in the saline douching alone group, whereas there were no cases in the combination group (p = 0.016). There were no significant differences in the rate of fertilization, morphologically good embryo acquisition, clinical and ongoing pregnancy between the two groups (p > 0.23). Conclusions: This large cohort study demonstrated that a combination of vaginal povidone iodine disinfection and subsequent saline douching is more effective procedure than saline douching alone to prevent OPU-PI, without spoiling the oocyte quality.
Oocyte pickup-associated pelvic inflammation
Povidone iodine
Saline douching
Vaginal preparation
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