Background: Pregnant women with chronic hypertension are at increased risk for complications. This study aims to investigate whethercalcium channel blockers plus low dosage aspirin therapy can reduce the incidence of complications during pregnancy with chronic hypertensionand improve the prognosis of neonates. Materials and Methods: From March 2011 to June 2013, 33 patients were selected tojoin this trial according to the chronic hypertension criteria set by the Preface Bulletin of American College of Obstetricians and Gynecologists, (ACOG). Patients were administrated calcium channel blockers plus low-dosage aspirin and vitamin C. The statistic data of baselineand prognosis from the patients were retrospectively reviewed and compared. Results: Blood pressure of patients was controlled bythese medicines with average systolic pressure from 146.3 to 148.7 mmHg and average diastolic pressure from 93.8 to 97.9 mmHg;39.4% patients complicated mild preeclampsia; however, none of them developed severe preeclampsia or eclampsia, or complicate placentalabruption. 30.3% patients delivered at preterm labour; 84.8% patients underwent cesarean section. The neonatal average weightwas 3,008 ± 629.6 g, in which seven neonatal weights were less than 2,500 g. All of the neonatal Apgar scores were 9 to 10 at one to fiveminutes. Small for gestational age (SGA) occurred in five (15%). Conclusions: Calcium channel blockers can improve the outcome ofpregnancy women with chronic hypertension to avoid the occurrence of severe pregnancy complication or neonatal morbidity.