Cite this article
The effect of clomiphene citrate vs. letrozole on post-coital tests
1 Cooper Medical School of Rowan University, Department of Obstetrics and Gynecology
1 Division of Reproductive Endocrinology & Infertility, Camden, NJ
2 Cooper Institute for Reproductive Hormonal Disorders, P.C., Mt. Laurel, NJ (USA)
Clin. Exp. Obstet. Gynecol. 2016 , 43(2), 184–185; https://doi.org/10.12891/ceog3288.2016
Published: 10 April 2016
Purpose: To determine if letrozole is less likely to create a hostile cervical mucus than clomiphene citrate. Materials and Methods: ost-coital testing compared at time of peak follicular maturation in women attaining mature follicles in first or second cycle of these wo drugs. The study was randomized. Intercourse occurred at least 8-16 hours before. Results: Poor post-coital tests were found in twice he frequency in letrozole cycles than clomiphene citrate cycles. Conclusions: Despite its shorter half-life, letrozole seems to be as least s likely, if not more, to adversely affect cervical mucus.