IMR Press / CEOG / Volume 43 / Issue 4 / DOI: 10.12891/ceog3233.2016
Open Access Original Research
Very unusual symptoms consistent with a possible migraine immediately following the injection of recombinant follitropin beta
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1 Cooper Medical School of Rowan University, Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology & Infertility, Camden, NJ
2 Cooper Institute for Reproductive Hormonal Disorders, P.C. Mt. Laurel, NJ (USA)
Clin. Exp. Obstet. Gynecol. 2016 , 43(4), 484–485; https://doi.org/10.12891/ceog3233.2016
Published: 10 August 2016
Abstract

Purpose: To present a new side effect of follitropin beta not shared with highly purified urinary follicle stimulating hormone (FSH). Materials and Methods: Follitropin beta was administered for preparation of in vitro fertilization-embryo transfer (IVF-ET). Results: Within a few minutes of injection of subcutaneously of follitropin beta, a 27-year-old woman developed a feeling of fever, headache, nausea, vomiting dizziness, and a visual aura consistent with migraine syndrome. These side effects did not occur when switched to highly purified urinary FSH. Conclusions: Since this reaction did not occur when injected with FSH not made with recombinant DNA technology, it is concluded that recombinant FSH (at least with follitropin beta) can produce an immediate migraine-like syndrome.
Keywords
Recombinant FSH
Follitropin beta
Migraine headaches
High purified urinary FSH
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