IMR Press / CEOG / Volume 44 / Issue 5 / DOI: 10.12891/ceog3478.2017
Open Access Original Research
Significance of growth differentiation factor 15 in primary ovarian insufficiency: inflammatory, biochemical, and hormonal correlates
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1 Department of Obstetrics & Gynecology, Dicle University School of Medicine, Diyarbakir, Turkey
2 Department of Obstetrics & Gynecology, Memorial Hospital, Diyarbakir, Turkey
3 Department of Obstetrics & Gynecology, Sirnak State Hospital, Sirnak, Turkey
4 Department of Medical Biochemistry, Dicle University School of Medicine, Diyarbakir, Turkey
Clin. Exp. Obstet. Gynecol. 2017 , 44(5), 730–733;
Published: 10 October 2017

Purpose: To investigate the levels of growth differentiation factor-15 (GDF-15) in primary ovarian insufficiency (POI) and to evaluate its correlation with hormonal, biochemical, and inflammatory indicators. Materials and Methods: This comparative, cross-sectional study was carried out in 60 cases consisting of 30 healthy controls (mean age: 29.2 ± 5.0 years) and 30 patients with POI (mean age: 28.9 ± 6.8 years). Two groups were compared in terms of serum levels of glucose, lipids, thyroid stimulating hormone (TSH), follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), prolactin (PRL), GDF-15, and neutrophil-lymphocyte ratios (NLR). Correlation between GDF-15 and NLR with these variables was sought. Results: Serum levels of FSH (p < 0.001), LH (p < 0.001), NLR (p < 0.001) and TSH (p = 0.020) were increased significantly in POI group. In POI patients, a correlation was detected between levels of GDF-15 levels and PRL (p = 0.049). Conclusion: The authors suggest that NLR can serve as a promising marker for diagnosis and follow-up of POI, whereas GDF-15 seems not to have such a potential.
Primary ovarian insufficiency
Growth differentiation factor-15
Neutrophil lymphocyte ratio
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