Objective: Amniotic fluid embolism (AFE) is a life-threatening obstetric complication characterized by sudden cardiac arrest, acute respiratory distress syndrome (ARDS), disseminated intravascular coagulation (DIC), seizures, and encephalopathy. Due to the difficulty of its diagnosis and management, its maternal and infant mortality becomes very high. Heparin plays an crucial role in DIC. However, there is no specific standard about the type and timing and dosage of heparin. Furthermore the pollution amniotic fluid has a tendency to cause infection and never attracts attention. Case Report: Here, the authors report a case of infection caused by AFE complicated with DIC. In this case, the patient was timely diagnosed with AFE when appeared with hypotension, pulmonary edema, and cyanosis during delivery. When the patient bled seriously and platelet and coagulation factors progressively decreased, the authors gave heparin to block the progress of DIC. Her vital signs became stable after she was accepted proper management. However, ultimately the patient died of septic shock. Conclusion: Early recognition and prompt initiation of proper management is critical in optimizing outcomes for the patient with AFE and the early small dose of heparin can cut the progression of DIC. Microbial invasion of amniotic fluid, once flowing into the blood circulation, is also likely to cause infection.