Purpose: To determine if treating with dextroamphetamine sulfate can relieve severe generalized idiopathic pruritus in an estrogen deficient woman taking an aromatase inhibitor for breast cancer. Materials and Methods: Dextroamphetamine sulfate 15 mg extended release capsules (as part of amphetamine salts) was prescribed. Results: Within one week the pruritus was completely dissipated and remained under total control for two months. She stopped the medication and the severe pruritus returned in three days. Resuming the amphetamine, the symptoms disappeared again and she has remained completely without symptoms for ten additional months while on medicine. Conclusions: It is not clear if the estrogen deficiency caused the pruritus by producing dry skin. Nevertheless, if a woman with estrogen deficiency complains of pruritus, but estrogen therapy is contraindicated, the treating physician could consider treating with dextroamphetamine sulfate. Of course this could be attempted in women with normal estrogen who have idiopathic pruritus in the absence of any noticeable skin lesions if other remediable causes, e.g., scabies, has been excluded.