IMR Press / CEOG / Volume 45 / Issue 5 / DOI: 10.12891/ceog4401.2018
Open Access Case Report
Prenatal diagnosis of a complex chromosomal rearrangement involving five chromosomes
Bo Wang1, †Dan Lu1, †Zuliang Shi1, †Jian Ke2, †Qi Zhao4Hongjun Li3, *
Show Less
1 Department of Clinical Laboratory, Hubei Maternal and Child Health Hospital, Wuhan, Hubei, PR China
2 Department of Health Care, Hubei Maternal and Child Health Hospital, Wuhan, Hubei, PR China
3 Department of Medical Ultrasonics, Hubei Maternal and Child Health Hospital, Wuhan, Hubei, PR China
4 Department of Clinical Laboratory, Dongsheng Area People's Hospital, Ordos, Inner Mongolia, PR China
† Contributed equally.
Clin. Exp. Obstet. Gynecol. 2018 , 45(5), 797–799; https://doi.org/10.12891/ceog4401.2018
Published: 10 October 2018
Abstract

The present authors report an exceptional complex chromosomal rearrangement involving five chromosomes. Cytogenetic analysis of cultured amniocytes revealed a unique karyotype of 46,X,t(X;13;9)(q13;q14;p22),t(3;6)(p13;q23) in 35/35 cultured amniocytes. Microarray- based comparative genomic hybridization (aCGH) revealed two microdeletions on chromosome Xq13.1-q13.2 and 13q14.2- q21.1 respectively. This study demonstrates the feasibility of using aCGH for prenatal diagnosis, especially in detecting subtle chromosomal abnormalities in high risk pregnancies.
Keywords
Karyotype analysis
aCGH
Reciprocal translocation
Prenatal diagnosis
Share
Back to top