IMR Press / CEOG / Volume 46 / Issue 6 / DOI: 10.12891/ceog4686.2019
Open Access Original Research
Relationships between vitamin D receptor genetic polymorphisms and endometriosis in Korean women
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1 Department of Obstetrics and Gynecology, College of Medicine, Soonchunhyang University Bucheon Hospital, Bucheon, Republic of Korea
2 Institute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan, Republic of Korea
3 Department of Chemistry, School of Natural Science, Dankook University, Cheonan, Republic of Korea
4 Department of Interdisciplinary Program in Biomedical Science, Soonchunhyang University Graduate School, Asan, Republic of Korea
5 Department of Biomedical Engineering, College of Medicine, Korea University, Seoul, Republic of Korea

Contributed equally.

Clin. Exp. Obstet. Gynecol. 2019 , 46(6), 876–880; https://doi.org/10.12891/ceog4686.2019
Published: 10 December 2019
Abstract

Objectives: Vitamin D and vitamin D receptor (VDR) are closely associated with both various immune system functions and estrogen-related pathways. The authors hypothesized that VDR genetic polymorphisms are associated with endometriosis risk. In this casecontrol study, the authors investigated the associations between polymorphisms in the VDR gene (FokI, BsmI, ApaI, and TaqI) and endometriosis risk. Materials and Methods: This case-control study included 30 women with endometriosis and 30 women without endometriosis. Genotyping of VDR polymorphisms was conducted using polymerase chain reaction and DNA sequencing. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to assess the association between the four VDR polymorphisms and endometriosis risk using Fisher’s exact test. Results: The four VDR genetic polymorphisms showed no significant associations with endometriosis risk. Similarly, a combination analysis indicated that no combinations of polymorphisms were associated with endometriosis risk. However, the present analysis combining three polymorphisms revealed very low ORs (CGGT: 0.536, TGTT: 0.250, and CGTT: 0.321). Conclusion: The present results suggest that VDR polymorphisms do not affect endometriosis risk in Korean women. However, the genotype frequencies of ApaI and TaqI differed between endometriosis patients and controls. Therefore, it is necessary to further validate the relationship between VDR polymorphisms and endometriosis risk in large-scale samples.

Keywords
Vitamin D receptor
Polymorphism
Endometriosis
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