IMR Press / CEOG / Volume 47 / Issue 4 / DOI: 10.31083/j.ceog.2020.04.5062
Open Access Case Report
The possible involvement of interleukin-6 in congestive heart failure in a postmenopausal woman with uterine fibromatosis
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1 Department of Obstetrics and Gynecology, Chibune General Hospital, Osaka, Japan
2 Department of Cardiovascular Medicine, Kyoto Chubu Medical Center, Kyoto, Japan
3 Department of Obstetrics and Gynecology, Kyoto Chubu Medical Center, Kyoto, Japan
Clin. Exp. Obstet. Gynecol. 2020 , 47(4), 590–595; https://doi.org/10.31083/j.ceog.2020.04.5062
Submitted: 20 November 2018 | Accepted: 21 January 2019 | Published: 15 August 2020
Abstract

Interleukin-6 (IL-6) has been shown to contribute to the progression of myocardial damage and dysfunction in congestive heart failure. We report a case of a 53-year old woman with congestive heart failure that may have been caused by IL-6 secreting uterine leiomyoma. The woman developed progressive dyspnea, pleural effusion, and leg edema with a decreased left ventricular ejection fraction (LVEF). Imaging studies indicated uterine leiomyoma compressing the vena cava. Due to unresponsiveness to conventional medical treatment, she underwent a total abdominal hysterectomy with bilateral salpingo-oophorectomy to alleviate compression of the vena cava. After surgery, pleural effusion and leg edema completely resolved. Concomitant with the subsequent improvement of LVEF, a pre-operative serum IL-6 measurement of 36.2 pg/mL fell to 1.6 pg/mL postoperatively. Immunologically positive staining for IL-6 was demonstrated in the cytoplasm of most of the uterine leiomyoma cells. These findings suggest that IL-6 produced by leiomyoma cells may have been involved in the pathophysiological progression of heart failure and associated hemodynamic changes.

Keywords
Leiomyoma
Interleukin-6
Heart failure
Pleural effusion
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