Purpose: This animal experiment investigated how sesame seed (Sesamum indicum; SSI) extract affects bone metabolism in ovariectomized (Ovx) rats. Materials and methods: Female Wistar rats (12 weeks old) were randomly assigned to the Baseline control (BC), Sham, Ovx, and Ovx + SSI groups (n = 6-10). Animals in the BC group were sacrificed immediately. Rats in the other groups underwent sham surgery (Sham) or bilateral ovariectomy (Ovx and Ovx + SSI). Rats in the Ovx + SSI group were given custom diets, and BMD and bone histomorphometry were evaluated 13 weeks post-surgery. Results: The femur BMD in the Ovx + SSI group was lower than in the Ovx group, as were the measurements for bone formation rate and mineralizing surface. Conclusion: Administration of a methanol extract of sesame seeds decreased femur BMD in Ovx rats.
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Original Research
Dietary sesame diminishes bone mass and bone formation indices in ovariectomized rats
R. Tachibana1, H. Matsushita1,*, A. Minami2, N. Morita1, S. Shimizu1, H. Kanazawa3, T. Suzuki2, K. Watanabe1, A. Wakatsuki1
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1
Department of Obstetrics and Gynecology, School of Medicine, Aichi Medical University, Nagakute, Aichi, Japan
2
Department of Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan
3
Department of Functional Anatomy, School of Nursing, University of Shizuoka, Shizuoka, Japan
*Correspondence: hirosm@aichi-med-u.ac.jp (HIROSHI MATSUSHITA)
Clin. Exp. Obstet. Gynecol. 2020, 47(4), 546–551;
https://doi.org/10.31083/j.ceog.2020.04.5144
Submitted: 1 February 2019 | Accepted: 1 April 2019 | Published: 15 August 2020
Copyright: © 2020 Tachibana et al. Published by IMR Press.
This is an open access article under the CC BY 4.0 license
http://creativecommons.org/licenses/by/4.0/.
Abstract
Keywords
Bone mineral density
Bone histomorphometry
Menopause
Ovariectomy
Rat
Sesame
Funding
Japan Society for Menopause and Women's Health to A.M.
Figures
Figure 1.