Academic Editor: Masatoki Kaneko
Background: We analyzed both early
and late (persistent) phases of each cytomegalovirus (CMV) antibody in mothers
with primary CMV infection during pregnancy and subsequent congenital CMV
infection for a long period from late pregnancy to after delivery using our
stored serum samples. Methods: We used stored serum samples
obtained during pregnancy to after delivery from mothers with CMV immunoglobulin
(Ig) G seroconversion and subsequent infant congenital CMV infection. CMV
antibodies, including CMV IgG titer, IgM titer, and IgG avidity, were assessed
using the Denka IgG assay, Denka IgM assay Ver.1 and Ver.2, and Enzygnost IgG
assay and Denka IgG avidity assay, respectively. We analyzed the dynamics of each
CMV antibody for a long period from late pregnancy to after delivery and
correlations of each antibody, calculating Pearson’s correlation coefficients
(R