Academic Editor: Shigeki Matsubara
Background: We aimed to evaluate the utility of C1 esterase inhibitor,
squamous cell carcinoma antigen, and complements C3 and C4 in the prediction of
fresh frozen plasma transfusion requirements in postpartum hemorrhage and
characterize the involvement of amniotic fluid embolism in the pathophysiology of
postpartum hemorrhage. Methods: In this single-centered prospective
observational study, consecutive patients with postpartum hemorrhage were
evaluated for C1 esterase inhibitor, squamous cell carcinoma antigen, C3 and C4.
We analyzed the relationship between the fresh frozen plasma transfusion volume
and the above-mentioned biomarkers. The interaction of low C1 esterase inhibitor
and squamous cell carcinoma antigen with respect to the fresh frozen plasma
transfusion volume was analyzed. Results: The analysis included
132 patients with postpartum hemorrhage. In univariate analysis, C1 esterase
inhibitor (correlation coefficient: –0.368, p