Background: Intrahepatic cholestasis of pregnancy (ICP) is a
common liver disorder specific to pregnancy. Taurocholic acid (TCA) has been
implicated in the pathogenesis of ICP. This study aimed to investigate the
association between serum TCA levels and adverse maternal and infant outcomes in
women with ICP. Methods: Pregnant women diagnosed with ICP were
categorized into normal or adverse groups based on their pregnancy outcomes.
Baseline data, including age, pre-pregnancy body mass index (BMI), systolic blood
pressure (SBP), diastolic blood pressure (DBP), and fasting blood sample (5 mL),
were collected at 28 weeks of gestation. Serum levels of total bile acid (TBA),
alanine transaminase (ALT), aspartate transaminase (AST), total bilirubin (TBIL),
and TCA were measured using a fully automatic biochemical analyzer. The
predictive value of serum TCA levels for adverse outcomes in ICP was analyzed
using receiver operating characteristic (ROC)
curve analysis. Subsequently, ICP patients were divided into high and low TCA
expression groups, and the changes in baseline data and adverse outcomes were
compared between the groups. The relationship between serum TCA levels and
adverse outcomes was evaluated using adverse maternal and infant outcome curves.
Logistic regression analysis was performed to identify independent risk factors
for adverse outcomes in ICP patients. Results: The
adverse outcome group showed significant differences in
gestational age at delivery (median value of 37 years old,
p = 0.0001), levels of TBA (mean
Announcements
Open Access
Original Research
Serum Taurocholic Acid Levels Have Predictive Value for Adverse Maternal and Infant Outcomes in Pregnant Women with Intrahepatic Cholestasis of Pregnancy: A Prospective Cohort Study
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1
Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Zhengzhou University, 450052 Zhengzhou, Henan, China
*Correspondence: Chenyan0541@163.com (Yan Chen)
Clin. Exp. Obstet. Gynecol. 2023, 50(12), 257;
https://doi.org/10.31083/j.ceog5012257
Submitted: 2 June 2023 | Revised: 10 August 2023 | Accepted: 24 August 2023 | Published: 12 December 2023
Copyright: © 2023 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.
Abstract
Keywords
intrahepatic cholestasis of pregnancy
adverse maternal and infant outcomes
taurocholic acid
total bile acids
alanine transaminase
aspartate transaminase
total bilirubin
Funding
LHGJ20190359/Joint construction project of Henan Province Medical Science and Technology Public Relations Plan
Figures
Fig. 1.