- Academic Editor
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Background: Polycystic ovary syndrome (PCOS) is commonly associated
with metabolic disorders. Abscisic acid (ABA), a plant hormone found in
vegetables and fruits that can be naturally supplied through dietary intake, has
previously been studied for its benefits to human health, particularly in people
with diabetes. ABA plays a key role in glucose metabolism, inflammation, and
tumor growth. The aim of this study was to investigate the therapeutic effect of
ABA on letrozole-induced PCOS rats. Methods: Wistar rats were implanted
with continuous-release letrozole pellets to induce a PCOS-like phenotype, and
subsequently treated with ABA or vehicle control. Body weight changes,
Testosterone (T) levels, fasting insulin measurements, and glucose tolerance
tests were investigated. A cell apoptosis model, induced by hydrogen peroxide
(H