- Academic Editor
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†These authors contributed equally.
Background: To improve the detection rate of chromosome abnormalities
in fetuses and to reduce the birth defects rate in elderly pregnant women using
chromosome karyotype analysis combined with the chromosome microarray analysis
(CMA) technique. Methods: Overall, 210 elderly pregnant women with
singleton pregnancies aged between 16 and 30 weeks (mean gestational age, 19.19
weeks) and 35 and 47 years (mean age, 38.08 years) were selected from January 1,
2020 to June 1, 2021 in the Eugenics Genetics Department of Yulin Maternal and
Child Health Hospital. Chromosome G banding karyotype analysis and CMA detection
were performed simultaneously. Results: Among the 210 elderly pregnant
women with singleton pregnancies, 26 (12.38%) and 52 (24.76%) cases were
detected as abnormal using chromosome karyotype analysis and CMA technology,
respectively. The abnormal CMA chromosomes’ total detection rate was 12.38%
higher than that using chromosome karyotype analysis (p