- Academic Editor
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†These authors contributed equally.
Background: We sought to explore the
potential relationship between serum levels of thyroid hormones with those of
androgen and metabolic parameters in women with polycystic ovary syndrome (PCOS).
Methods: Data from 1059 Chinese women with PCOS and 1015 healthy women
was retrospectively collected. This data including fasting glucose and insulin,
thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), free thyroxine
(FT4), total triiodothyronine (TT3), total thyroxine (TT4), anti-thyroperoxidase
antibody (ANTI-TPO), anti-thyroglobulin (ATG), dehydroepiandrosterone sulfate
(DHEAS), total testosterone (TTE), follicle-stimulating hormone (FSH),
luteinizing hormone (LH), estradiol (E2), prolactin (PRL), progesterone (PGN),
triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol
(HDL) and low-density lipoprotein cholesterol (LDL). Thyroid-related indicators
were compared between PCOS and non-PCOS patients enrolled in this study.
Independent variables of PCOS were compared among subgroups in accordance with
the classification of TSH, homeostatic model assessment of insulin resistance
(HOMA-IR), and TTE levels. To further explore the association between thyroid
hormones levels and correlated metabolic parameters in PCOS, multiple regression
analyses were conducted. Results: Our study found that PCOS
patients had significantly higher serum TSH, FT3, TT3 and TT4 levels than
non-PCOS patients. PCOS patients with TSH