The Authors report their personal observations of nipple discharge in gynecologic patients admitted to the Obstetric and Gynecologic Department of Padua University or applying to the Senologic Diagnostic- or Endocrinology-Departments of the same. After dividing breast secretions into two groups - the neuroendocrine and the strictly mammary ones - the Authors discuss their etiopathogenesis, incidence, and clinical significance (mainly as to their possible association to breast malignancies), and present their personal results. At the end, a careful examination of all nipple discharges is recommended, which should include, besides cytological evaluation, a complete assessment of the neuroendocrine function and a watchful investigation of local breast conditions.