Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.
, Fernando Abdulkader 2, Eduardo Rebelato 2, Talita Romanatto 2, Carlos Hermano J. Pinheiro 2, Kaio Fernando Vitzel 2, Erica Portioli Silva 2, Roberto B. Bazotte 3, Joaquim Procopio 2, Rui Curi 2, Renata Gorjao 4, Tania Cristina Pithon-Curi 41 UCD School of Biomolecular and Biomedical Science, UCD Conway Institute and UCD Institute for Sport and Health, UCD Dublin, Belield, Dublin 4, Ireland. philip.newsholme@ucd.ie
2 Department of Physiology and Biophysics, Institute of Biomedical Sciences, University Sao Paulo (USP), Sao Paulo, Brazil
3 State University of Maringa (DFF/UEM), Department of Pharmacy and Pharmacology, 87020- 900, Maringa, PR, Brazil
4 Institute of Physical Activity Sciences and Sports, Post-Graduate Program in Human Movement Sciences, Cruzeiro do Sul University, Sao Paulo, Brazil
Abstract
Aberrant alterations in glucose and lipid concentrations and their pathways of metabolism are a hallmark of diabetes. However, much less is known about alterations in concentrations of amino acids and their pathways of metabolism in diabetes. In this review we have attempted to highlight, integrate and discuss common alterations in amino acid metabolism in a wide variety of cells and tissues and relate these changes to alterations in endocrine, physiologic and immune function in diabetes.