- Academic Editor
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Background: To analyze the polymorphism distribution of low density
lipoprotein receptor rs688, AvaII, NcoI gene in
ischemic stroke, and explore the linkage disequilibrium among them. The
correlation between the linkage disequilibrium and ischemic stroke was further
analyzed. Methods: The levels of serum lipid (triglyceride, cholesterol,
high density lipoprotein cholesterol, low density lipoprotein cholesterol,
apolipoprotein A1, apolipoprotein B) and rs688, AvaII,
NcoI polymorphism of low density lipoprotein receptor gene were tested
in patients with ischemic stroke (n = 140), healthy control (n = 129) and
patients with other cerebrovascular diseases (n = 122). Chi-square test was used
to compare the gene frequency and allele frequency of each group. Both the
linkage disequilibrium of the three genes and the alleles correlated with
ischemic stroke were analyzed. The correlation of linkage disequilibrium gene and
ischemic stroke was analyzed with logistic binary regression. Results:
In the ischemic stroke group, significant difference was observed in frequencies
and allelic frequencies of low density lipoprotein receptor (LDLR) rs688
and AvaII. No difference of NcoI was found. Linkage
disequilibrium was found for rs688 and AvaII (D’ = 0.927,
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