IMR Press / JIN / Volume 22 / Issue 4 / DOI: 10.31083/j.jin2204102
Open Access Systematic Review
The Efficacy and Safety of Different Noninvasive Therapies in the Treatment of Central Poststroke Pain (CPSP): A Network Meta-Analysis and Systematic Review
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1 Department of Rehabilitation Medicine, General Hospital of Xinjiang Military Region, 830002 Urumchi, Xinjiang, China
2 School of Clinical Medicine, Southwest Medical University, 646099 Luzhou, Sichuan, China
3 Department of Rehabilitation Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, 610072 Chengdu, Sichuan, China
4 Department of Traditional Chinese Medicine, Chengdu Second People's Hospital, 610021 Chengdu, Sichuan, China
5 School of Clinical Medicine, Hospital of Chengdu University of Traditional Chinese Medicine, 610032 Chengdu, Sichuan, China
*Correspondence: alis7718@outlook.com (Ruo-Yang Li)
J. Integr. Neurosci. 2023, 22(4), 102; https://doi.org/10.31083/j.jin2204102
Submitted: 6 February 2023 | Revised: 14 March 2023 | Accepted: 20 March 2023 | Published: 20 July 2023
Copyright: © 2023 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.
Abstract

Objective: To evaluate the efficacy and safety of noninvasive therapies in the treatment of central poststroke pain (CPSP) by network meta-analysis and to provide an evidence-based basis for clinical practice. Methods: PubMed, Cochrane Library, EMBASE, CNKI, Wanfang, and VIP were searched for clinical randomized controlled studies on noninvasive therapy for CPSP. The retrieval time limit was from the establishment of each database to July 2022. The bias risk assessment tool recommended by Cochrane was used to evaluate the quality of the included randomized controlled trials (RCTs). Stata 14.0 was used for network meta-analysis, and Review Manager 5.3 software was used for traditional meta-analysis. Results: Twelve RCTs involving 8 treatment schemes and 641 patients were finally included. The results of the network meta-analysis showed the following rankings in visual analysis scale (VAS): super laser injury on stellate ganglia (SLI) > transcranial direct current stimulation (tDCS) > music therapy (MT) > repetitive transcranial magnetic stimulation (rTMS) > continuous theta burst stimulation (cTBS) > transcutaneous acupoint electrical stimulation (TAES) > common therapy (CT). The total clinical efficiency ranked as follows: psychological training of mindfulness (PT) > rTMS > CT. Clinical adverse reactions ranked as follows: rTMS > MT > CT > SLI. Conclusions: Noninvasive complementary therapy can effectively alleviate the pain of CPSP patients, and the efficacy and safety of SLI are relatively significant. However, due to the limitations of this study, the efficacy ranking cannot fully explain the advantages and disadvantages of clinical efficacy. In the future, more multicentre, large sample, double-blind clinical randomized controlled trials are needed to supplement and demonstrate the results of this study.

Keywords
noninvasive therapies
CPSP
Network meta-analysis
VAS
Figures
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