- Academic Editor
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Background: The cerebellum is an area of the brain that is prone to
damage in individuals with Alzheimer’s disease (AD). As a non-pharmacological
intervention for AD, exercise training has shown an ameliorating effect on AD
pathology; however, the target regions have mostly been the cerebral cortex and
hippocampus. The main aim of this study was to explore the influence of 12 weeks
of treadmill running on the accumulation of AD-related proteins, dysfunction of
mitochondria, and subsequent neuronal cell death in the cerebellum of triple
transgenic (3xTg-AD) mice. Methods: Four-month-old 3xTg-AD mice were
allocated into two groups: an AD control group (AD, n = 10) and an AD exercise
group (AD-Exe, n = 10). The AD-Exe mice underwent training on a motorized animal
treadmill 5 days a week for 12 weeks. After sacrifice, the cerebellum was
collected and biochemically analyzed. Results: The AD-Exe mice expressed
reduced levels of extracellular