Background: Mitochondrial dysfunction is one of the major hallmarks of
Parkinson’s disease (PD). Recently, angiotensin II type 1 and type 2 receptors
(AT1R, AT2R) were reported to be present on the mitochondrial membrane. Both are
crucial players in the brain renin-angiotensin system (RAS). Current evidence
indicates that blockade of brain AT1R protects dopaminergic neurons in PD.
Methods: Thus, the current study was aimed to explore the effects of
Telmisartan (Tel), a selective AT1R blocker, on mitochondrial function and a
mouse model by exposure to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)
[250 mg/kg body weight (10 divided i.p. injections, each 25 mg/kg body weight at
3.5 days interval) + Probenecid 250 mg/kg]. Gait function was assessed by beam
walk, and mice were euthanized on the 35th day and their brain tissues isolated
for Western blot analysis. Results: Pretreatment with Tel significantly
protected motor functions during the beam walk in MPTP-treated mice. Tel
attenuated the increased levels of AT1R,
Announcements
Open Access
Original Research
Telmisartan Protects Mitochondrial Function, Gait, and Neuronal Apoptosis by Activating the Akt/GSK3β/PGC1α Pathway in an MPTP-Induced Mouse Model of Parkinson's Disease
Bipul Ray1,2,3, Sunanda Tuladhar1,2, Pramod Gudigenahally Nagaraju4,5, Ashwini Shivalinga4,5, Arehally Marappa Mahalakshmi1, Poornima Priyadarshini4,5, Byoung-Joon Song3, Saravana Babu Chidambaram1,2,6,*
Show Less
1
Department of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education & Research (JSS AHER), 570015 Mysuru, India
2
Centre for Experimental Pharmacology and Toxicology, Central Animal Facility, JSS Academy of Higher Education & Research, 570015 Mysuru, India
3
Section of Molecular Pharmacology and Toxicology, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892, USA
4
Department of Molecular Nutrition, Council of Scientific and Industrial Research (CSIR)—Central Food Technological Research Institute, 570020 Mysuru, India
5
Council of Scientific and Industrial Research (CSIR), Academy of Scientific and Innovative Research (AcSIR), 201002 Ghaziabad, India
6
Brain, Behavior and Cognitive Neurosciences Research (BBCR), JSS Academy of Higher Education & Research, 570015 Mysuru, India
*Correspondence: babupublications@gmail.com; saravanababu.c@jssuni.edu.in (Saravana Babu Chidambaram)
J. Integr. Neurosci. 2024, 23(2), 29;
https://doi.org/10.31083/j.jin2302029
Submitted: 31 August 2023 | Revised: 16 October 2023 | Accepted: 18 October 2023 | Published: 4 February 2024
Copyright: © 2024 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.
Abstract
Keywords
Parkinson's disease
renin-angiotensin system
mitochondria
telmisartan
MPTP
Adenosine triphosphate (ATP)
Funding
No-45/3/2019-PHA/BMS/OL/Indian Council of Medical Research (ICMR)
Figures
Fig. 1.