- Academic Editor
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†These authors contributed equally.
Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by the
onset of symptoms, typically occurring later in life, and significant deficits in
cognitive functions including learning, memory, speech, and behavior. Ongoing
research endeavors seek to explore methods for preventing and treating AD, as
well as delving into the molecular mechanisms underlying existing and novel
therapeutic approaches encompassing exercise, diet, and drug regimens for
individuals with AD or those at risk of developing AD. Among these interventions,
dietary interventions have garnered increasing attention due to their potential
in addressing the disease. Eating is among the most fundamental of human daily
activities, and controlled dietary practices, such as fasting, have gained
prominence as essential clinical methods for disease prevention and treatment.
Research findings indicate that fasting holds promise in effectively alleviating
and improving the cognitive decline associated with age or as consequence of
disease. The clinical efficacy of fasting in addressing AD and related disorders
might be grounded in its influence on various molecular mechanisms, including
neuroinflammation, glial cell activation, insulin resistance, autophagy
regulation, nerve regeneration, the gut microbiome, and accumulations of
amyloid-