- Academic Editor
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†These authors contributed equally.
Background: It has been reported that ferroptosis participates in the
pathophysiological mechanism of spinal cord injury (SCI). Our preliminary
experiments verified that dendrobium nobile polysaccharide (DNP) improved the
behavioral function of SCI rats. Therefore, the purpose of this study was to
examine the role of DNP on ferroptosis and its neuroprotective mechanism in SCI
rats. Methods: Adult female sprague dawley (SD) rats were
exposed to SCI by Allen’s method, followed by an intragastric injection of 100
mg/kg DNP per day for 2 weeks. Behavioral features were verified by the
Basso-Beattie-Bresnahan (BBB) scale and footprint evaluation. Iron content and
glutathione (GSH) were assessed spectrophotometrically. Mitochondrial
morphology was examined by transmission electron microscopy. The expression of
ferroptosis-related genes, including System Xc