Several evidences have shown that the tumor microenvironment (TME) can reprogram tumor initiation, growth, invasion, metastasis, and response to therapies. Indeed, the TME has been recognized as a major contributor to cancer malignancy and therapeutic resistance. The TME comprises the surrounding blood vessels, signaling molecules, the extracellular matrix (ECM) and multiple stromal cells, including cancer-associated fibroblast (CAFs), tumor-associated macrophages (TAMs), among others. The presence of these cellular components has been associated with poor prognosis and unfavorable outcomes in different types of cancers. Therefore, therapies that simultaneously target tumor cells and TME components may represent a key strategy to overcome drug resistance and improve patient outcomes. This Special Issue includes original research articles focusing on novel bioactive compounds or small molecules (chemically synthesized or of natural origin), or repurposed drugs, that target TME elements to improve cancer therapy. Review articles will also be considered.
Dr. Cristina P. R. Xavier
Manuscripts should be submitted via our online editorial system at https://jour.ipublishment.com/imr/access/login by registering and logging in to this website. Once you are registered, click here to start your submission Manuscripts can be submitted now or up until the deadline. All papers will go through peer-review process. Accepted papers will be published in the journal (as soon as accepted) and meanwhile listed together on the special issue website. Research articles, reviews as well as short communications are preferred. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office to announce on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts will be thoroughly refereed through a double-blind peer-review process. Please visit the Instruction for Authors page before submitting a manuscript. The Article Processing Charge (APC) in this open access journal is 500 USD. Submitted papers should be well formatted and use good English.