IMR Press / RCM / Volume 13 / Issue 2-3 / DOI: 10.3909/ricm0602
Open Access Review
Contribution of Right Ventricular Dysfunction to Heart Failure Mortality: A Meta-Analysis
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1 Department of Cardiology, Hospital of the University of León, León, Spain
2 Institute of Biomedicine, University of León, León, Spain
Rev. Cardiovasc. Med. 2012 , 13(2-3), 62–69;
Published: 30 June 2012
Right ventricular systolic dysfunction (RVSD) has been related to prognosis in patients with heart failure (HF) and/or left ventricular systolic dysfunction. However, most of the studies addressing this issue are not large enough, have different inclusion criteria, and use different methods to evaluate RV function to draw definite conclusions. We sought to investigate the association between RVSD and outcomes in patients with left ventricular dysfunction. Eleven studies of 40 (27.5%), with 4732 patients, were included in the meta-analysis. RVSD was present in 2234 patients (47.2%). Four of the studies had admission for HF as an endpoint. We found a significant association between RVSD and overall mortality with significant between-studies heterogeneity and presence of publication bias (funnel plot). A significant association was found between RVSD and admission for HF. RVSD is associated with overall mortality and admission for HF during follow-up. Significant between-studies heterogeneity and publication bias must be taken into account when interpreting this information.
Right ventricular systolic dysfunction
Left ventricular systolic dysfunction
Heart failure
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