Academic Editors: Alessandro Zorzi, Peter H. Brubaker and Kazuhiro P. Izawa
Background: Aerobic high-intensity interval training (HIIT) has
demonstrated benefits for ventricular remodeling after myocardial infarction (MI)
through various mechanisms. Despite this, the optimal training volume is not well
known. The present study aimed to assess the effects of different (low vs. high
volume) aerobic HIIT compared to an attentional control (AC) group on
echocardiographic and biochemical indicators of left ventricular (LV) remodeling
in adults after MI. Methods: Randomized clinical trial conducted on
post-MI patients with preserved ventricular function. Participants were assigned
to three study groups. Two groups performed HIIT 2 d/week, one group with
low-volume HIIT (20 min, n = 28) and another with high-volume HIIT (40 min, n =
28). A third group was assigned to AC (n = 24) with recommendations for
unsupervised aerobic training. Left ventricular echocardiographic parameters and
cardiac biomarker levels (N-terminal pro-b-type natriuretic peptide, NT-proBNP; soluble
growth stimulation expressed gene 2, ST2; troponin T; and creatine kinase) were assessed
at baseline and after the intervention (16 weeks). Results: Eighty participants (58.4