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- Academic Editor
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†These authors contributed equally.
Background:The
atherogenic index of plasma (AIP), determined by the logarithmic transformation
of the ratio of triglyceride (TG) and high-density lipoprotein cholesterol
(HDL-C), was found to be a marker of cardiovascular disease. We sought to
investigate the correlation between the atherogenic AIP and coronary collateral circulation (CCC) formation in
chronic total occlusive (CTOs) patients. Methods: This
retrospective cohort study included 665 non-CTOs and 345 CTOs patients. CTOs were
divided into 206 CCC poor formation patients and 139 CCC good formation patients
according to the Cohen-Rentrop grade. Spearman correlation analysis was carried
out to obtain the relationship between AIP and the Rentrop grade. We used
multivariate logistic regression analysis to assess CTOs and CCC poor formation
risk factors. Receiver operating characteristic (ROC) curves were used to
determine the optimal threshold for AIP to predict CTOs and CCC poor formation.
The predicted increment of AIP on CTOs and CCC poor formation was evaluated by
calculating the Net Reclassification Index (NRI) and the Integrated Discriminant
Index (IDI). Results: AIP in CTOs was significantly elevated compared to
non-CTOs patients [(1.55 (1.02, 2.59)) vs (1.26 (0.82, 1.90)),
p