- Academic Editors
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†These authors contributed equally.
Background: Peripheral myopathy consists a hallmark of heart failure
(HF) and has been associated with poor prognosis. Inflammation has been suggested
to dominate this pathology, while exercise training is typically associated with
the induction of anti-inflammatory mechanisms. However, the current knowledge
regarding the involvement of inflammation-related genes in the exercise
training-induced muscle adaptations in HF patients is very limited. Given that
high-intensity interval training (HIIT) alone or combined with strength training
(COM) has gained ground in HF cardiac rehabilitation, this study aimed to
investigate the local muscle expression of inflammatory and tissue remodeling
factors in HF patients, who underwent 3 months of these training schemes. In
addition, we examined whether these exercise training-induced gene expression
responses are associated with changes in exercise capacity in those patients.
Methods: Thirteen male patients with chronic HF (age: 51