Background: It is well documented that menopause is linked to an
increased risk of cardiovascular (CV) events; however, the results of studies
focusing on the association between premature ovarian insufficiency (POI) and the
risk of CV events are controversial. The aim of this systematic review and
meta-analysis was to assess the risk of CV events among women with POI compared
to women with menopausal aged 50–54 years. Methods: A systematic literature
search of PubMed (including Medline), Scopus, and Web of Science was conducted
from 1990 to 2022 to retrieve observational studies published in
English-language. The studies’ quality was assessed using structured standard
tools. Primary-outcome was the pooled risk of the composite outcome of CV events.
Results: We included 16 studies involving 40,549 women who suffered from POI and
1,016,633 women as controls. After adjustment for hormone therapy, the pooled
risk of composite outcome of CV events and coronary heart disease, among women
with the POI was significantly 1.3 (Pooled-adjusted hazard ratio (HR) = 1.35,
95% CI: 1.06–1.63, I
Announcements
Open Access
Systematic Review
Cardiovascular Events Among Women with Premature Ovarian Insufficiency: A Systematic Review and Meta-Analysis
Samira Behboudi-Gandevani1,*, Ellen Christin Arntzen1, Britt Normann1, Tommy Haugan2, Razieh Bidhendi-Yarandi3
Show Less
1
Faculty of Nursing and Health Sciences, Nord University, 8049 Bodø, Norway
2
Faculty of Nursing and Health Sciences, Nord University, 7629 Levanger, Norway
3
Department of Biostatistics, University of Social Welfare and Rehabilitation Sciences, 1985713871 Tehran, Iran
*Correspondence: samira.behboudi-gandevani@nord.no (Samira Behboudi-Gandevani)
Rev. Cardiovasc. Med. 2023, 24(7), 193;
https://doi.org/10.31083/j.rcm2407193
Submitted: 3 February 2023 | Revised: 15 April 2023 | Accepted: 5 May 2023 | Published: 4 July 2023
(This article belongs to the Special Issue Cardiovascular Disease in Women)
Copyright: © 2023 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.
Abstract
Keywords
cardiovascular events
premature ovarian insufficiency
systematic review and meta-analysis
Figures
Fig. 1.