Background: A potential relationship between oral inflammation and
cardiovascular disease has been proposed; however, the impact of cardiovascular
disease on implant restoration remains unclear. This systematic review aims to
assess the relationship between peri-implantitis and cardiovascular disease based
on review of data obtained through observational studies. Materials and
Methods: An extensive systematic literature search was performed using the
PubMed/MEDLINE, Scopus, Web of Science and Cochrane Library databases. Studies
published in English language up to June 2022 were conducted in accordance with
PRISMA guidelines. These efforts identified 230 unique publications and, after
selection, five studies were included in this meta-analysis. The Newcastle-Ottawa
Scale table was used for literature quality assessment. A fixed-effect model was
selected and RevMan software version 5.3 was used to identify the origin of the
outcomes of the meta-analysis. Finally, results were reported through the PRISMA
statement. Results: This meta-analysis found that in implant restoration
the incidence of peri-implantitis in patients with cardiovascular disease was
higher than those without cardiovascular disease (Risk ratio (RR) = 1.12; 95%
CI: 1.02–1.23; z = 2.34; p
Announcements
Open Access
Systematic Review
Association between Cardiovascular Diseases and Peri-Implantitis: A Systematic Review and Meta-Analysis
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1
School & Hospital of Stomatology, Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, 200072 Shanghai, China
2
Department of Oral Implantology, School & Hospital of Stomatology, Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, 200072 Shanghai, China
*Correspondence: miss.fanzhen@tongji.edu.cn (Zhen Fan)
Rev. Cardiovasc. Med. 2023, 24(7), 200;
https://doi.org/10.31083/j.rcm2407200
Submitted: 5 December 2022 | Revised: 31 December 2022 | Accepted: 12 January 2023 | Published: 13 July 2023
(This article belongs to the Special Issue Inflammation and Cardiovascular Diseases)
Copyright: © 2023 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.
Abstract
Keywords
dental implants
cardiovascular diseases
epidemiology
inflammation
biomarkers
peri-implantitis
Funding
2021YFC2400400/2021 Key Special Project of National Key R&D Plan
202040094/Scientific research project of Shanghai Municipal Health Commission
Figures
Fig. 1.