†These authors contributed equally.
Background: Women are frequently underrepresented in clinical trials
and databases focusing on ventricular arrhythmias (VAs). However, understanding
sex-based differences in risk factors and the prognosis of VAs is essential for
tailoring personalized prevention and treatment strategies. This study aimed to
investigate sex differences in the epidemiology, risk factors, and prognosis of
VAs in patients with sepsis. Methods: We conducted a comprehensive
analysis of 27,139 sepsis patients (mean [SD] age, 66.6 [16.2] years; 15,626
[57.6%] male), among whom 1136 (4.2%) developed VAs during their
hospitalization. We evaluated VAs incidence and potential risk elements in both
male and female patients, along with in-hospital mortality. Results: Men
had a significantly higher likelihood of developing VAs compared to women (odds
ratio [OR]: 1.70, 95% confidence interval [CI]: 1.50–1.94, p