The cyclic guanosine monophosphate-adenosine monophosphate (GMP-AMP) synthase (cGAS)-stimulator of interferon genes (STING) pathway is a part of the innate immune system that plays a role in the cardiovascular system. It acts as a surveillance system, detecting and responding to cytosolic DNA, viral DNA, and other intracellular DNA species. Activation of the cGAS-STING pathway leads to the production of inflammatory cytokines and type I interferons, which are involved in the immune response. In the cardiovascular system, the cGAS-STING pathway has been implicated in various physiological and pathological processes. It contributes to vascular inflammation, atherosclerosis, endothelial dysfunction and cardiac remodeling and heart failure. In this review, we will elaborate on the research progress of the role of cGAS-STING in cardiovascular system.