IMR Press / CEOG / Volume 48 / Issue 1 / DOI: 10.31083/j.ceog.2021.01.5417
Open Access Original Research
Effective doses 50% and 95% of subarachnoid injection of sufentanil with ropivacaine in lumbar anesthesia for cesarean section in severe preeclampsia
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1 Department of Anaesthesia, Fujian Maternity and Child Health Hospital, Affiliated Hospital of Fujian Medical University, 350001 Fuzhou, P. R. China
Clin. Exp. Obstet. Gynecol. 2021 , 48(1), 105–109; https://doi.org/10.31083/j.ceog.2021.01.5417
Submitted: 22 March 2020 | Revised: 15 July 2020 | Accepted: 22 July 2020 | Published: 15 February 2021
Abstract

Objective: This study aimed to determine the ED50 and ED95 of 10 mg of 0.5% ropivacaine combined with different doses of sufentanil in lumbar anesthesia for cesarean sections in patients with severe preeclampsia by the sequential method. Methods: A total of 47 patients with severe preeclampsia, who underwent cesarean section, were enrolled in the present study. The first patient was given a subarachnoid injection of 10 mg of isobaric 0.5% ropivacaine plus 2.5 μg of sufentanil. If the anesthetic effect was satisfactory, the dose of sufentanil used for the next patient was reduced by 0.5 μg. If the anesthetic effect was unsatisfactory, the dose of sufentanil used for the next patient was increased by 0.5 μg. Results: The ED50 of sufentanil was 1.830 μg, with a 95% CI ranging within 1.517-2.128 μg, while the ED95 of sufentanil was 2.852 μg with a 95% CI ranging within 2.429-4.338 μg. Conclusion: The ED50 and ED95 of 10 mg of isobaric 0.5% ropivacaine combined with different doses of sufentanil in lumbar anesthesia for cesarean sections in patients with severe preeclampsia were 1.830 μg and 2.852 μg, respectively.

Keywords
Ropivacaine
Sufentanil
Severe preeclampsia
Cesarean section
Dose-effect relationship
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