Effective doses 50% and 95% of subarachnoid injection of sufentanil with ropivacaine in lumbar anesthesia for cesarean section in severe preeclampsia

Objective: This study aimed to determine the ED50 and ED95 of 10 mg of 0.5% ropivacaine combined with different doses of sufentanil in lumbar anesthesia for cesarean sections in patients with severe preeclampsia by the sequential method. Methods: A total of 47 patients with severe preeclampsia, who underwent cesarean section, were enrolled in the present study. The first patient was given a subarachnoid injection of 10 mg of isobaric 0.5% ropivacaine plus 2.5 $\mu$ g of sufentanil. If the anesthetic effect was satisfactory, the dose of sufentanil used for the next patient was reduced by 0.5 $\mu$ g. If the anesthetic effect was unsatisfactory, the dose of sufentanil used for the next patient was increased by 0.5 $\mu$ g. Results: The ED50 of sufentanil was 1.830 $\mu$ g, with a 95% CI ranging within 1.517-2.128 $\mu$ g, while the ED95 of sufentanil was 2.852 $\mu$ g with a 95% CI ranging within 2.429-4.338 $\mu$ g. Conclusion: The ED50 and ED95 of 10 mg of isobaric 0.5% ropivacaine combined with different doses of sufentanil in lumbar anesthesia for cesarean sections in patients with severe preeclampsia were 1.830 $\mu$ g and 2.852 $\mu$ g, respectively.

Keywords

Ropivacaine

Sufentanil

Severe preeclampsia

Cesarean section

Dose-effect relationship

Figures

Fig. 1.

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Clin. Exp. Obstet. Gynecol. Print ISSN 0390-6663 Electronic ISSN 2709-0094