Academic Editor: Josef Jampílek
Introduction: Aerosolised drugs have been approved for several diseases
such as cystic fibrosis and diabetes. Moreover; there are already drugs for
pulmonary hypertension in aerosol form already on the market. Materials
and methods: Two drugs for pulmonary hypertension (Tadalafil and Macitentan)
were milled and transformed from tablets to powder. Three different
jet-nebulizers with seven different residual cups were combined. Moreover, we
used 3 different ultrasound nebulizers with two different release methods.
Results: The drug and residual cup designs produce alone or jointly
different MMAD diameters. The three large (10 mls) residual cups with the
jet-nebulisers produced the smallest aerosol droplets. Both ultrasound nebulisers
are capable of producing optimal size aerosol droplets