Dear Colleagues,
Autophagy is a catabolic process by which obsolete or damaged components of the cell are delivered to the lysosome for degradation. Autophagy is essential for maintaining cellular homeostasis. Three types of autophagy are defined based on the mechanism by which cytosolic material is delivered to the lysosome: macroautophagy, microautophagy, and chaperone-mediated autophagy (CMA). Unfortunately, autophagic activity declines with aging, and compromised autophagy is a hallmark of aging. Defective autophagy with age contributes to the loss of proteostasis in old organisms, leading to the accumulation of damaged macromolecules, organelles, and proteinaceous aggregates and ultimately causing toxicity in tissues and organs. Given that autophagy failure contributes to the worsening of multiple age-related diseases, a better understanding of the basics of age-related decline of autophagy is imperative to develop a means to enhance autophagy as future therapeutic tools.
This Special Issue offers the opportunity to contribute and publish research findings, reviews, and perspectives. We encourage the submission of manuscripts with a focus on cellular and molecular biology that cover autophagy-related topics in the context of aging and age-related diseases.
This Special Issue will cover the following topics:
- Pathological impact of autophagy on aging and age-related diseases.
- In vivo and in vitro models for studying the significance of autophagic failure in normal aging and age-related diseases.
- Novel use of nutritional compounds, phytocompounds, plant extracts, and pharmacological drugs to boost autophagic function.
- Different strategies to boost autophagic function and prevent the deleterious effects of aging.
- Epidemiological studies providing information about autophagy malfunction and age-related debilities.
- Use of antioxidants in aging models and their impact on the interplay between oxidative stress and autophagy in aging and aging-related diseases.
Dr. Eloy Bejarano Fernandez, Dr. Marina García Macia and Dr. Lucia Gimeno Mallench
Guest Editors
Manuscripts should be submitted via our online editorial system at https://imr.propub.com by registering and logging in to this website. Once you are registered, click here to start your submission. Manuscripts can be submitted now or up until the deadline. All papers will go through peer-review process. Accepted papers will be published in the journal (as soon as accepted) and meanwhile listed together on the special issue website. Research articles, reviews as well as short communications are preferred. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office to announce on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts will be thoroughly refereed through a double-blind peer-review process. Please visit the Instruction for Authors page before submitting a manuscript. The Article Processing Charge (APC) in this open access journal is 2500 USD. Submitted manuscripts should be well formatted in good English.