Dear Colleagues,
Glomerular disease encompasses a group of conditions affecting glomeruli, crucial kidney structures responsible for blood filtration. Common types of glomerular disease include diabetic kidney disease, focal segmental glomerulosclerosis, lupus nephritis, membranous nephropathy, IgA nephropathy, minimal change disease, and anti-glomerular basement membrane (anti-GBM) disease otherwise known as Goodpasture’s disease. It is now clear that metabolic and immunologic factors are primary contributors to glomerular disease development.
Recent studies identify innate immunity as a key player in glomerular disease pathogenesis, and that this involves various immunomodulatory mechanisms. Kidney-resident immune cells, as well as parenchymal cells, widely express transmembrane and intracellular pattern recognition receptors (PRRs), which are essential to kidney homeostasis mediated by innate immune response. However, PRRs may be also activated by endogenous molecules termed damage-associated molecular patterns (DAMPs), which include nucleic acids, ATP, or proteins. Therefore, mitochondria, as the evolutionary remnants of ancestral alphaproteobacteria, have an important role in controlling aseptic inflammation through signaling pathways such as cGAS-STING, TLR9, RIG-I, and MDA5, all of which mediate cell death mechanisms.
We invite contributions to the forthcoming special issue 'Innate Immunity in the Pathogenesis of Glomerular Diseases' to advance our understanding of how kidney-resident immune cells, aseptic inflammation, and their potential cross-talk contribute to glomerular disease development and progression. We welcome basic research as well as review articles that explore new mechanisms related to the role of innate immunity in the development and progression of glomerular disease, as well as novel insight into potential novel treatment strategies.
Dr. Alla Mitrofanova
Guest Editor
Manuscripts should be submitted via our online editorial system at https://imr.propub.com by registering and logging in to this website. Once you are registered, click here to start your submission. Manuscripts can be submitted now or up until the deadline. All papers will go through peer-review process. Accepted papers will be published in the journal (as soon as accepted) and meanwhile listed together on the special issue website. Research articles, reviews as well as short communications are preferred. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office to announce on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts will be thoroughly refereed through a double-blind peer-review process. Please visit the Instruction for Authors page before submitting a manuscript. The Article Processing Charge (APC) in this open access journal is 2500 USD. Submitted manuscripts should be well formatted in good English.