Dear Colleagues,
Protein kinases selectively modify other proteins by covalently adding phosphates as opposed to kinases which modify lipids, carbohydrates, or other molecules. Protein kinases are mainly categorized into two groups: Serine/threonine kinases, which phosphorylate the hydroxyl groups of serines and threonines in their targets, and tyrosine kinases, which phosphorylate tyrosine amino acid residues.
Protein kinases play a pivotal role in the pathogenesis of numerous diseases. While protein kinases are essential for cellular signaling processes such as growth, differentiation and apoptosis, dysregulation is frequently implicated in the pathophysiology of various diseases. Aberrant kinase activity can lead to uncontrolled cell proliferation and tumor formation. Kinase dysfunction is also associated with neurological disorders, such as Alzheimer's and Parkinson's disease. Additionally, protein kinases play a crucial role in metabolic diseases such as diabetes and obesity, acting central to the intricate signaling networks related to glucose and lipid metabolism.
Understanding the intricate roles of protein kinases in various diseases is crucial for the development of targeted therapies that aim to restore cellular balance and alleviate the suffering of affected individuals. In this Special Issue, we invite colleagues to submit original research and literature reviews on the role of protein kinases in diseases, and the possible interventions that can help to regulate them to support therapeutic interventions.
Prof. Jinbong Park, Prof. Ji Hoon Jung and Dr. Hyo In Kim
Guest Editors
Manuscripts should be submitted via our online editorial system at https://imr.propub.com by registering and logging in to this website. Once you are registered, click here to start your submission. Manuscripts can be submitted now or up until the deadline. All papers will go through peer-review process. Accepted papers will be published in the journal (as soon as accepted) and meanwhile listed together on the special issue website. Research articles, reviews as well as short communications are preferred. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office to announce on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts will be thoroughly refereed through a double-blind peer-review process. Please visit the Instruction for Authors page before submitting a manuscript. The Article Processing Charge (APC) in this open access journal is 2500 USD. Submitted manuscripts should be well formatted in good English.