Dear Colleagues,
The ability of cancer cells to adjust their metabolism in response to environmental changes is a well-recognized hallmark of cancer. Cancer cells have been shown to not only use glucose for generating cellular energy but also glutamine, thereby reducing power and metabolic building blocks for biosynthesis. Additionally, cancer cells generate most of their cellular energy via mitochondrial respiration and oxidative phosphorylation. Multiple metabolic pathways are known to play a role in cancer metastasis, including glycolysis, the pentose phosphate pathway, the tricarboxylic acid cycle, oxidative phosphorylation, amino acid metabolism, and fatty acid metabolism. Importantly, cancer cells exhibit remarkable versatility in the use of bioenergetic substrates, and can for example use metabolic substrates donated by stromal cells for cellular energy generation via oxidative phosphorylation. A better understanding of tumor bioenergetics will provide a more holistic approach for the investigation of cancer biology and therapeutics.
This special issue seeks to gather cutting-edge research articles and review papers that examine the intricate relationship between mitochondrial bioenergetics and tumor biology. The aim is to increase our understanding of how mitochondrial bioenergetics can be exploited for effective cancer treatment. This can be achieved by examining the impact of mitochondrial metabolism on cancer cell function, identifying signaling pathways that are regulated by energy metabolism, and exploring novel therapeutic strategies based on mitochondrial bioenergetics.
Topics of Interest:
We invite original research articles, reviews and perspectives that address (but are not limited to) the following topics:
Metabolic rewiring in cancer cells: Understanding alterations in mitochondrial bioenergetics.
Role of mitochondrial oxidative phosphorylation (OXPHOS) and glycolysis in cancer cell metabolism.
Modulation of mitochondrial function as a strategy to sensitize cancer cells to conventional therapies.
Exploiting mitochondrial bioenergetics for the development of novel therapeutic interventions.
Biomarkers of mitochondrial dysfunction and therapeutic response in cancer patients.
Translational and clinical applications of targeting mitochondrial bioenergetics in cancer treatment.
Metabolic reprogramming in cancer cells and its impact on bioenergetics.
Mitochondrial dysfunction and bioenergetic adaptations in cancer cells.
Lipid metabolism and its contribution to bioenergetics in cancer cells.
Signaling pathways and transcriptional regulators involved in regulating cancer cell bioenergetics.
Imaging techniques for studying bioenergetics in cancer cells.
Translational implications and therapeutic strategies targeting cancer cell bioenergetics.
Dr. Chen Li
Guest Editor
Manuscripts should be submitted via our online editorial system at https://imr.propub.com by registering and logging in to this website. Once you are registered, click here to start your submission. Manuscripts can be submitted now or up until the deadline. All papers will go through peer-review process. Accepted papers will be published in the journal (as soon as accepted) and meanwhile listed together on the special issue website. Research articles, reviews as well as short communications are preferred. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office to announce on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts will be thoroughly refereed through a double-blind peer-review process. Please visit the Instruction for Authors page before submitting a manuscript. The Article Processing Charge (APC) in this open access journal is 2500 USD. Submitted manuscripts should be well formatted in good English.