Dear Colleagues,
This issue will focus on the molecular pathology of the skeleton in response to circulatory alterations, its disorganization in selected diseases, and the resulting clinical consequences. Both osteoblasts and osteoclasts are highly sensitive to their biophysical environment and can alter their cytokine expression profiles in response to changes in fluid flow, pressure, oxygenation, etc. The subsequent effects can be seen and characterized by functional imaging. The altered cytokine environment contributes to several skeletal diseases, including osteoarthritis. Articles for this issue may include:
- perfusion abnormalities in preclinical models of osteoarthritis,
- clinical perfusion disorders in human osteoarthritis,
- avascular necrosis including coagulopathies,
- the biomechanical sequelae of intraosseous hypertension leading to the enigmatic condition of bone marrow edema and its treatment implications,
- the movement of molecules through bone fluids, including fibrinolysis.
Prof. Dr. Roy K. Aaron
Guest Editor
Manuscripts should be submitted via our online editorial system at https://imr.propub.com by registering and logging in to this website. Once you are registered, click here to start your submission. Manuscripts can be submitted now or up until the deadline. All papers will go through peer-review process. Accepted papers will be published in the journal (as soon as accepted) and meanwhile listed together on the special issue website. Research articles, reviews as well as short communications are preferred. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office to announce on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts will be thoroughly refereed through a double-blind peer-review process. Please visit the Instruction for Authors page before submitting a manuscript. The Article Processing Charge (APC) in this open access journal is 2500 USD. Submitted manuscripts should be well formatted in good English.