- Academic Editor
-
-
-
Background: Chronic pain refers to pain that persists for over three
months. Chronic pain may restrict activities of daily living, including work,
learning, social life, and can lead to anxiety, depression, and sleep
disturbance. Imaging data have demonstrated that central sensitization often
occurs in the brain of patients with chronic pain, which arises from imbalanced
neurotransmission in the central nervous system. Transient receptor potential
vanilloid 1 (TRPV1) is an ion channel to serve as an inflammatory detector in the
brain. We aim to determine the properties of acupoint catgut embedding (ACE) on
cold stress-induced mice fibromyalgia (FM) and surveyed the character of TRPV1
and linked molecules in chronic FM pain. Methods: Intermittent cold
stress (ICS) was used to induce mice FM model. Mice were subgrouped into normal
mice, ICS-induced FM group, FM mice with ACE, and FM in Trpv1