- Academic Editors
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Background: Current evidence suggests that Gamma-aminobutyric acid
(GABA) receptors are associated with the occurrence and progression of
cerebrovascular diseases. The present study investigated the association between
single nucleotide polymorphisms (SNPs) in the Gamma-aminobutyric acid type A
receptor gamma2 subunit (GABRG2) gene and ischemic stroke (IS).
Methods: A total of 120 healthy volunteers and 187 patients with IS were
recruited. Patients underwent complete neurological assessment and classification
with the National Institute of Health Stroke Scale (NIHSS) and the Trial of ORG
10172 in Acute Stroke Treatment (TOAST). Polymerase chain reaction-restriction
fragment length polymorphism (PCR-RFLP) was used to analyze SNP sites in 4
different regions (rs211037, rs418210, rs211035, and
rs424740) of the GABRG2 gene. SHEsis online platform was used
to assess SNP allele and genotype frequencies. Multivariate logistic regression
analysis was performed to identify the risk factors for IS. Results:
Univariate analysis showed that the T allele and
TT genotype distribution for rs211037 were significantly more
frequent in the IS group compared to controls (p